Tamil Nadu Public Service Commission Exam Syllabus

Paper - I

Section A | Section B | Section C


Section A
Molecular Pharmacology
Drug Receptors
Chemical Bonds
Drugs And Enzymes
Structure Activity Relationship
Cellular Pharmacology
Biological Membrane And Transport Accross Membranes
Drug Effect On Extra Cellular. Tissue Ingredients.
Integral Pharmacology
Pharmacokinetics
Principal Effects Of Drugs
Side Effects Of Drugs
Complex Drug Actions - Commulation, Tolerence, Synergism, Antagonism, Potentiation.
Pharmacogenetics
Drug Selectivity
Chemotheraphy
General Principles Of Chemotheropy
Chemotherapy Of Infectious Diseases
Chemotherapy Of Malignancy
Quantative Aspects In Pharmacology
Dose Response Relationship
Bioassay
Chemical Assay
Radio Immuno Assay
Drug Standardization
Pharmacological Screening Of Siddha Medicinal Preparations
Selection Of Plants, Minerals And Animal Products Used In Siddha Medicine
Extraction,Preparation And Screening Of Pharmacologically Active Principles In Various Experimental Models.

Biostatistics

Centering Constants; Means, MedianAndMode, Variability Constants - Average, Range,Interquartile Range, Average Deviation, Standard Deviation; Tests Of Significance Student'sTest, Chi Square Test, Anova, Application Of Statistics In Evaluation Of Siddha And Herbal Preparations And Formulations.


Section B - General Principles Of Toxicology

Introduction To Toxicology - Toxicology - Definition And Branches - Classification Of Toxic Agents.
Toxins - Acute And Chronic Exposure - Route, Site, Duration And Frequency Of Exposure.
Spectrum Of Toxic Effects - Allergic And Idiosyncratic Reactions; Toxicity; Immediate And Delayed; Reversible And Irreversible; Local Systemic And Selective.
Toxicokinetics - Abserption, Distribution, Metabolism And Excretion And Influencing Factors.
Dose - Response Relationship - Ld 50, Ed 50
Mechanism Of Action.
Chemical - Chemical Interaction, Chemical - Diet Interation - Potentiation, Synergism And Antagonism.
Factors Influencing Toxicity - Factors Related To The Agent, Exposure Situation And Internal Environment Of The Subject, External Enviornmental Factors.
ToxicityTestsInAnimals-Acute,Subacute And ChronicTests Mutagenicity,Teratogenicity And 0.Carcinogenicity Tests, Interpretation Of Laboratory Data.
Treatment And Management Of Poisoning - Antidotal Principles And Their Application.


Section C - Instrumentation
Thin Layer Chromatography & Paper Electrophoresis
U.V. - Vis Spectro Photometry - Differential Spectrophotometry
Infra-Red Spectrophotometry - Interpretation Of Spectra.
NMR Spectorphotometry And Its Applications.
Mass Spectrometry As Applied To Drugs Analysis
Gaschromatography & G C - Ms Techniques.
Atomic Absorption Spectrophotometry And Neutron Activation
Analysis As Applied To Elemental Analysis.
X-Ray Diffraction In Toxicological Analysis
High Performance Liquid Chromatography In Toxicology
Radio Immuno Assay In Analysis Of Body Fluids For Poisons.

Paper - II


Section A | Section B | Section C


Section A
Drugs Acting On Various Systems
Cns
Ans
Respiratory
Cardio Vasular
Gastrointestinal
Genito Urinary
Musculo Skeletal
Reproductive Pharmacology
Drugs Acting On The Male & Female Reproductive System
Antifertility Agents
Hormone Replacement Therapy
Hormones And Hormone Antagonists
Endocrinological Disorders And Drug Treatment
Anti Diabetic Drugs
Anti Thyroid Drugs
Hormone Replacement Therapy in Endocrinological Disorders
Vitamins, Minerals And Nutritional Supplements
Deficiencies And their Drug Treatment.
Analgesic, Anti Pyretic And Antinflammartory Drugs - Drugs Used In Inflammatory Disorders - Anti Artheritic, Gout Drugs.
Chemotherapy - General Principles - Chemotherapy Of Infectious Diseases, Chemotherapy Of Malignancy.

Section B
Preliminaries - Central & Peripherac Nervous Systems Neuro Transmitters
Drug Addiction & Habituation
Drug Dependence
Social & Personality Factors Conductive To Drug Dependence
Dependence Potential And Dependence Liability
Narcotic Analgesies
Cannabis And Cannabenoids
Psychotogenic Drugs.
Amphetamines.
Cocaine And Erythroxylon Coca
Mono Amine Oxidase Inhibitors - Triexelic Antidepressants
Xanthine Beverages And Xanthine Alkaloids
Abuse Of & Toxicity Associated With Hypnotics And Seditives.
Barbiturates
Benzodiazepines
Miscellaneous
(i) Acute & Chronic Toxicity Associated With Abeottol Abuse
(ii) Toxicity & Treatment Associated With Methanol Poisioning
Abuse Of Inhalants & Glue Sniffing.
Tobacco Smoking - Tobacco Use - Toxicity & Complications Associated With
Treatment & Prevention Of Drug Addiction.
Siddha & Other Methods Associated With The Treatment & Prevention Of Drug Addiction
Siddha Drugs In Preventing & Treating Drug Toxicity Associated With Liver And Other Organs.
Experimental Techniques In Evaluating The Addiction Potential And Liability Of A Drug.


Section C - Forensic Toxicology
Poisons Acts And Type Of Poisoning In India.
Mode Of Action of Poisons.
Causes Which Modify The Effects
Corrosive Poisons
Metals And Their Salts And Methods Of Estimation
Volatile Poisons - Mode Of Action And Analysis
Insecticides
Synthetic Drugs
Plant Poisons And Animal Poisons-Isolation From Body Fluids.
Extraction And Purification In Toxicological Analysis.
Screening Tests For Common Poisons.
Gas Analysis.
Glycosides And Alkaloids And Analysis From Biological Fluids
Barbiturates And Other Synthetic Drugs
Metabolic Pathways Of Poisons