Pharmacy Syllabus of TNPSC

Pharmacy - (Code - 092)
Paper I
Paper II

Paper - I
Pharmaceutics


I

1) Pharmaceutical technology
2) Formulative & Industrial pharmacy
3) Physical Pharmacy
4) Hospital & clinical pharmacy
5) Bio Pharmaceutics

II Bio Technology

III Forensic Pharmacy

Pharmacy Act 1948 Drugs & Cosmetics Act 1940 Narcotic & Psychotropic Substances Act.

PHARMACY - IPharmacology, Pharmacognosy, Pharmaceutical Chemistry
Chemistry of Natural Products
Medicinal Chemistry
Modern method of pharmaceutical analysis

PHARMACY - II PHARMACEUTICS :

I Pharmaceutical Technology :-
The Physical Physico-Chemical and Engineering Principles governing design, lay-out and operation of plants for the process employed in Pharmaceutical Industry - Size Reduction, Size seperation, mixing, compression, filtration, centrifugation, Extraction, Evaporation, Drying, Distillation, Crystallization.
Safety methods of Pharmaceutical laboratories and work.
containers and closures and packaging technology.

II Hospital and Clinical Pharmacy -
Hospital Pharmacy - its aims, organisation, personnel and functions.
Drug Distribution system in Hospital.
Drug information centre
Purchasing, inventory control and pricing of drugs.

III
Clinical Pharmacy - its concept and functions.
Design and optimization of dosage regimen
Therapeutic drug mointoring
Adverse drug reactions.

IV Formulative and Industrial Pharmacy :- (I) Preformulation Studies:- Dosage form Necessities :- Antioxidant, Preservatives, Colouring, Flavouring and Sweetenning agents, Solvents Facts related with formulation, Physical properties, particle size, crystal form, flow cohesiveness, solubility, Chemical properties, hydrolysis, oxidation, racenization enzymatic decompositions.

V Technology of Drug Delivery Systems :- Good Manufacturing Practice, Standards, Presents labelling packing, and storage, quality assurance and quality control of formulation belonging to the following categories. Semisolid Preparations:- Ointments, Pastes, Creams, gels Jellies and Suppositories. Solid dosage forms:- Powders, Tablets, Capsules Liquid dosage forms:- Mixtures, Elixirs, Syrups, Collodions throatpaints, and enemas, official in various pharmacopoeias.Parentral and opthalmic Preparations:- Injections, Sterile powders, Depots, Implants, eye drops and eye ointments. New Drug Delivery Systems:- Aerosols, Occusert, Transdermal Drug delivery, Osmotic drug delivery, Targetted drug delivery systems, Radio Pharmaceuticals. Cosmetics:- Dentrifrices, Lipstick, face powders, shampoos, deplitatories and manicure preparations.

VI Community Pharmacy :- Dispensing and compounding Procedures and containers and closures for packaging, with regard to-Mixtures, emlusions, applications, inhalations, spray solutions, powders, powders in hard gelatin capsules, tablet triturates, mouthwash, gargles, eyelotion, douches.

VII Application of computer in pharmacy :- Physical Pharmaceutics:- Principles related with Rheology, surface and interfacial phenomenon, Soulbilization, Thermodynamics, Complexation and protein binding.

VIII Bio Pharmaceutics:- Basic of Pharmacodynamic and pharmacekinetic and their importance in formulation.

IX Pharmaceutical Bio - Technology :-
Bio - Chemical role of hermenes, vitamines, enzymes and nuclic acids.
Principles involved and apparatus used in the analysis of blood, urine, gastric, juices, faeces etc.
General principles of immunology, Immunology techniques used in pharmacy.
Sterilization of different pharmaceutical desage forms.
Steribility testing
Methods of Preparation of official Sera and Vaccines.
Microbiological assays of the pharmacopoeia
Applications of Micro - organisms in bio-conversions and pharmaceutical industry.
X Forensic Pharmacy :-
Pharmacy act 1948
Drugs and cosmetics Act - 1940 - Rules 1945
Narcotic and Psychotropic drugs act 1986.

Paper - II

Pharmacology

General Pharmacology:- Routes of administration - Absorption, distribution, Biotransformation & Extretion of drugs. - Bioavailability and bio equivalence - Factors affecting bioavaliability. - Mechanism of action of drugs at receptor level - adverse drug reaction
Drugs acting on Central Nervous system:- - Analgesics - Nensterodial anti inflammatory drugs - Sedatives and Hypnotics - Anti convulsants and Antipsychotic drugs. - Central Nervous System stimulants, which are in frequent use (or) which are of toxicological importance.
Drugs acting on Autonomic Nervous system:- - Drugs which influence the working of autonomic nervous system - Adrenergic drugs (or) sympathominitic drugs - Adrenergic blocking drugs. - Cholinergic drugs and cholinergic blocking drugs. - Drugs acting on autonomic ganglia - Drugs used in parkinsonism and Myasthenia gravis
Drug acting on Gardiovasular system cardiac glycosides, Anti typertensive, anti array thmic, and anti anginal drugs.
Diuretics of anti diuretics.
Insulin and oral anti diabetic drugs, Thyroid and antithroidal drugs, oral contraceptives, Hormone replacement thereapy, family planning methods.
Study of Antihistaminics, and drugs acting on uterus.
Chemotherapy of infections diseases sulphonamides, penicillins, - antibiotics Chemotheraphy of Tuberculosis - leprosy malaria, cancer Ameebiasis, Helminthisis and veneral diseases.
Toxicology:- Systematic & local treatment of poisoning and their treatment.
Principles of biological assay, classification, with examples from therapeutics and also listed in I.P.

PHARMACOGNOSY
General principle of cultivation and collection of drugs from wild & cultivated sources, their merits and demerits factors affecting. Plant growth regulators, Basics of genetic engineering, drug detnoration - causative factors prevention. Adulteration and its detection.
Pharmacognositc scheme work of (source, synomym, Cultivation. Collection, Preparation for market, diagnostic charactors (both macroscopical and microscopical), constituents, substitutents, adulterants and uses of) Cinnamon, Cinchona, Seena, Digitalis, Clove, saffron Pyrethrum, cochineal, Ergot, opium, Aloe, Acacla, Tragacanth, Benzoin, Ginseng, Brahmi, Diosoorea, Cascara, Gelatin umbelliforous fruits.
Basic concept involved in Ayurveda, Siddha, Unani, Naturopathy.
Principle and Application of plant tissue culture
Basics of fermentation technology & production of Antibiotics, Vitamins.
Principle & Application of Tracer technique.
Biosythetic pathways of Tropane alkaloids, cholesterol, amino acids.
Definition, classification with structures, physical, chemical properties and functions, of Alkaloids, Glycosides, Resins, Tannins, Terpenes, Carbohydrates, Volatile oils, fixed oils, with Examples.
Drug evaluation.
Phytochemical - Investigation of drugs (Screening methods) including modern analytical techniques.

PHARMACEUTICAL CHEMISTRY
Chemistry of Natural Products:- Familiarity with methods of structure elucidation and biosythesis of Alkaloids, Terpenrs, Steroids, Carbohydrates, Proteins. Methods of extraction, classification, Chemistry Assay and Medicinal uses of polysaccharides, amino acids, pepticles, Glycosides, Vitamins and Hormones.
Miedicinal Chemistry:- Definition, classification, sythesis, properties, test for purity, common names structure, storage of drugs possessing the Following pharmacological action. Analgesics and Antipyretics, Antihistamines, Hypnotics and sedatives, antimalarials, antibiotic, antihypertensives, sulphonamideo Anti psychotic drugs, cardiac drugs diusetics.
Pharmaceutical Analysis:- Assay procedure of advances types from the I.P. with special reference to the procedure and techniques involving Non-Aqucous titrations, oxidation - reduction, diazotization and complexometric methods and grammetric analysis.
Chromatography
This layer chromatography
Column "
Paper "
Gas "
Ion exchange "
Gel electro phorosis
Theory, principle instruments involved and application of colosimetry UV and visible spectrometry, Fluorimetry, Nephalemetry, Tuebisimetry, potentiometric titration, conductometric, titration, polarography, amperometric titration. Basic of I.R. MASS, NMR